Patient-specific brain targeting
for functional neurosurgery
Real-world outcomes that reshape care
for Parkinson’s Disease and Essential Tremor
Rebrain is a spin-off of the University Hospital of Bordeaux and the Inria, based in the EU and the US, created by Professor Emmanuel Cuny, Neurosurgeon, and Professor Nejib Zemzemi, Researcher at Inria in Applied Mathematics, after 10 years of academic research and 2 theses.
Rebrain’s service is a best-in-class, supervised AI-driven solution that streamlines complex, patient-specific neurosurgery by providing faster, simpler, and safer treatment through augmented neuromodulation planning.
Regulatory
CE marked,
FDA 510(k) cleared
Adoption
60+ sites
worldwide
Indications
Parkinson’s disease (STN),
Essential tremor (VIM)
Volume
1 000+ targeting
operations performed
From T1 MRI upload to surgery planning,
Rebrain services streamlines the pre-surgical planning process.
We have developed a targeting service that uses supervised AI algorithm & health data exchange platform to simplify and standardize neurosurgical procedures.
Our solution seamlessly integrate supervised AI-guided targeting into any workflow to streamline and standardize neurosurgical procedures.
* Rebrain’ service leverages CE Marked and FDA 510(k) cleared Software as a Medical Device (SaMD), OptimMRI and OptimDBS.
1
Upload
VIM or STN, left, right, or bilateral
2
Data Processing
18 landmarks per hemisphere
3
Download
ready-to-use MRI
Online secured portal
Answer 5 case questions
Rebrain Neuro operator supervised
Crosshair on desired target(s)
Raw DICOM with target overlay
Works with your existing setup
With Rebrain, we aim to enhance efficiency and peace of mind
for neurosurgeons and staff by providing millimetric MRI-guided
targeting of the STN or VIM based on a health data exchange platform.
Seamless integration
Surgery
under GA
Fast
workflow
Precise
surgery
Safe and efficient
Real Life impact
Testimony of a Parkinsonian patient treated on with the help of Rebrain’ services
Testimony of an Essential Tremor patient treated on with the help of Rebrain’ services
Real Life impact
Testimony of a Parkinsonian patient treated on with the help of Rebrain’ services
Testimony of an Essential Tremor patient treated on with the help of Rebrain’ services
Marked MRI
worldwide
best-in-class
clinical data
Key anatomical
landmarks
Our latest public updates
Rebrain unveils its identity: a strong vision for the future of assisted neurosurgery
At Rebrain, innovation has never been an end in itself. It has always been a means to improve the precision of neurosurgical procedures and to have a concrete impact on patients’ lives. Today, we are reaching a new stage of our development with the official launch of...
RebrAin 2025/2026: Expanding Reach, Driving Innovation
Transatlantic expansion RebrAIn’s focus for 2026 is expanding our reach to major neurosurgery reference centers in the US and Europe. Today, our top partner centers by volume are Duke University, University of Virginia (UVA), Pamplona and UCLA. These collaborations...
Rebrain publishes OPTIVIM trial results in Neurosurgery
An innovative and automated method RebrAIn’s service is based on a machine learning model trained on data from successfully treated patients. Using only a standard 3D T1 MRI, the algorithm automatically computes the stereotactic coordinates of the optimal DBS target,...